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Vol. 143, No. 8, August 2012, pp. 44-59

 

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Quartz Crystal Microbalance DNA Based Biosensor for Diagnosis: A Review

 

1 Thongchai KAEWPHINIT, 3 Somchai SANTIWATANAKUL and 2 Kosum CHANSIRI

1 Graduate School of Srinakharinwirot University, Sukhumvit 23, Bangkok 10110, Thailand

Tel.: +66 22664-1000 ext 4619, fax: +66 2260-0125

2 Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Sukhumvit 23, Bangkok, 10110, Thailand

Tel.: +66 2260-2122 ext 4605, fax: +66 2260-0125.

3 Department of Pathology, Faculty of Medicine, Srinakharinwirot University, Sukhumvit 23, Bangkok, 10110, Thailand

E-mail: tkaewphinit@yahoo.com, tkaewphinit@yahoo.com, kosum@swu.ac.th, titi41@yahoo.com

 

 

Received: 4 July 2012   /Accepted: 21 August 2012   /Published: 28 August 2012

Digital Sensors and Sensor Sysstems

 

Abstract: Generally, the detection of particular DNA sequence is carried out by gel electrophoresis of DNA fragments amplified by polymerase chain reaction (PCR) using primers which are specific complementary sequence with the chosen region of DNA. Although gel electrophoresis is simple and effective for detection of PCR products, the use of carcinogenic ethidium bromide as a common stain is risky and hazardous. The DNA quartz crystal microbalance (DNA-QCM) lays the groundwork for incorporating the method for rapid DNA analysis. QCM biosensor is an extremely sensitive mass sensor, capable of measuring picogram levels of mass changes. This is a great potential market for simple, cheap, rapid, and quantitative detection of specific genes. QCM requires any non-labeling such as radio isotope, enzyme, and fluorescence tag.

 

Keywords: Biosensors, Quartz crystal microbalance, DNA, Immobilization, Hybridization

 

 

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