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Vol. 149, No. 2, February 2013, pp. 60-68

 

Bullet

 

Surface Plasmon Resonance Biosensor
 
1 Nina GRIDINA, 2 Gleb DOROZINSKY, 2 Roman KHRISTOSENKO, 2 Vladimir MASLOV, 2 Anton SAMOYLOV, 2 Yury USHENIN, 2 Yury SHIRSHOV
 

1 Institute of neurosurgery n. acad. A. Romodanov AMS of Ukraine, 32, Platona Mayborody st., 04050, Kiev, Ukraine

2 V. Ye. Lashkaryov Institute of Semiconductor Physics of NAS of Ukraine,

45, Prospekt Nauki, 03028, Kiev, Ukraine

E-mail: vladmaslov@mail.ru

 

 Received: 15 January 2013   /Accepted: 14 February 2013   /Published: 28 February 2013

Digital Sensors and Sensor Sysstems

 

Abstract: Performed in this paper is numerical modeling of the angular dependence for light reflectivity R(F) in surface plasmon-polariton resonance (SPR) realized in Kretschmann geometry when studying the interface gold/suspension of spherical particles (cells) in the assumption that the dielectric permittivity of particles suspension   is described by the theory of effective medium. It has been shown that availability of suspended particles in solution inevitably results in appearance of an intermediate layer with the ε gradient between gold surface and suspension bulk, as a result of which the SPR angle shifts to lower values. Near the critical angle, the first derivative dR/dF demonstrates a clearly pronounced peak, which allows determining the   value for suspension bulk and the   gradient in the intermediate layer. Obtained in our experiments were SPR curves for two suspensions of erythrocytes the dense one (erythrocyte mass after centrifuging) and loose solution (whole blood). In the case of erythrocyte mass, fitting the experimental and calculated curves enabled us to quantitatively determine the bulk    value for this erythrocyte mass (εb =1.96), thickness of the intermediate layer dm (300400 nm) and    gradient in the intermediate layer. On the contrary, the SPR curve for whole blood appeared to be close to that of pure plasma. This fact allows only estimation of the thickness dm~2000...3000 nm as well as minimum ε value in the intermediate layer, which is close to that of plasma (ε = 1.79). Also, discussed is the mechanism of influence of the cell shape near the gold surface on the SPR effect.

 

Keywords: Surface plasmon-polariton resonance (SPR), Liquid suspensions, Weighted erythrocytes, Biosensor, Blood sensor

 

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