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Vol. 149, No. 2, February 2013, pp. 129-134




Frequency Domain Analysis of Intracellular Ion Transport through Lipid Bilayer Membrane Based on Aldosterone Activity Concomitant  
with Neurohormonal Interaction
Suman Halder

ST. Thomasí College of Engg & Technology,

Kolkata-700023, India



Received: 30 November 2012   /Accepted: 14 February 2013   /Published: 28 February 2013

Digital Sensors and Sensor Sysstems


Abstract: In this present paper we have made a conscious effort to develop a model based on aldosterone activity on cellular ion transport concomitant with neurohormonal interaction. To investigate this physiological phenomenon we have proposed a novel approach which is closed loop frequency analysis of above phenomena associated with Connís Syndrome and Addisonís disease. Thus this model predicts how the characteristics of the lipid bilayer membrane changes with the effect of neurotransmitters concomitant with aldosterone secretion. The change in the characteristics of lipid bilayer membrane is of prime importance because it can completely alter the body functions. This model has been simulated by using MATLAB procedure in order to facilitate comprehensive understanding of complex membrane dynamics in response to neurohormonal agents. A control system design approach utilizing bode plot procedure is implemented to determine frequency band width of the lipid bilayer membrane based on the model fit to experimental data. Finally it has been investigated how aldosterone secretion is affected by change physiological property of subjects and the results are compared with recent experimental findings.


Keywords: Bandwidth, frequency response, time constant, lipid bilayer membrane, sodium ion concentration, potassium ion concentration


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