bullet Sensors & Transducers Journal

    (ISSN 1726- 5479)

 

 

25 Top Downloaded Articles

Editorial Calendar 2007

Submit an Article

Editorial Board

Sensors and Transducers journal's cover

 

2000-2002 S&T e-Digest Contents

2003 S&T e-Digest Contents

2004 S&T e-Digest Contents

2005 S&T e-Digest Contents

 
   

 

 

Vol. 76, Issue 2, February 2007, pp. 969-977

 

Bullet

 

Interface Layering Phenomena in Capacitance Detection of DNA with Biochips

 

Sandro Carraraa*, Frank K. Gürkaynakb, Carlotta Guiduccic, Claudio Stagnic, Luca Beninic, Yusuf Leblebicib, Bruno Samorìa, Giovanni De Michelib

aBiochemistry Department, University of Bologna, Bologna, Italy

bEcole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

c DEIS Department, University of Bologna, Bologna, Italy

*Via Irnerio, 48 - 40126 Bologna, Phone.+39 0512094388, E-mail: sandro.carrara@unibo.it

 

 

Received: 2 February 2007 / Accepted: 22 February 2007 / Published: 26 February 2007

 

Abstract: Reliable DNA detection is of great importance for the development of the Lab-on-chip technology. The effort of the most recent projects on this field is to integrate all necessary operations, such as sample preparation (mixing, PCR amplification) together with the sensor user for DNA detection. Among the different ways to sense the DNA hybridization, fluorescence based detection has been favored by the market. However, fluorescence based approaches require that the DNA targets are labeled by means of chromophores. As an alternative label-free DNA detection method, capacitance detection was recently proposed by different authors. While this effect has been successfully demonstrated by several groups, the model used for data analysis is far too simple to describe the real behavior of a DNA sensor. The aim of the present paper is to propose a different electrochemical model to describe DNA capacitance detection.

 

Keywords: DNA Biochip, capacitance detection, ion layering, constant phase elements

 

Acrobat reader logo Click <here> or title of paper to download the full pages article (479 K)

 

 

 

 


1999 - 2007 Copyright ©, International Frequency Sensor Association (IFSA). All Rights Reserved.


Home - News - Links - Archives - Tools - Standardization - Patents - Marketplace - Projects - Wish List - Subscribe - Search - e-Shop - Membership

 Members Area -Sensors Portal -Training Courses - S&T Digest - For advertisers - Bookstore - Forums - Polls - Sensor Jobs - Site Map