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Vol. 191, Issue 8, August 2015, pp. 84-99




Early Forming a Hummingbird-like Hovering Neural Network Circuitry Pattern with Reentrant Spatiotemporal Energy-Sensory Orientation Privileged to Avoid “Epilepsy” Based on a Biomimetic Acetylcholinesterase Memcapacitor Prosthesis

1 * Ellen T. Chen, 2 John T. Thornton and 3 Charlie Mulchi, Jr.

1Advanced Biomimetic Sensors, 11140 Rockville Pike Suite 400, Unit 422 Rockville, MD 20852, USA
2 Bruker Nano, 19 Fortune Dr., Billerica, MA 01821, USA
3 Armo Case, 14020 Crest Hill Lane, Silver Spring, MD 20905, USA
1 Tel.: 301-528-2273

1 E-mail: ellenchen@nanobiomimeticsensors.com


Received: 24 June 2015 /Accepted: 30 July 2015 /Published: 31 August 2015

Digital Sensors and Sensor Sysstems


Abstract: The hummingbird’s significant asymmetry hovering flight with energy conservation pattern is remarkable among all vertebrates. However, little is known to human’s neuronal network circuitry current flow pattern for whether or not has this privilege during slow wave sleeping (SWS). What is the advantage in order to avoid diseases if we have this network pattern ? A memory device was developed with nanostructured biomimetic acetylcholinesterase (ACHE) gorge membrane on gold chips as memcapacitor 1, served as a normal brain network prosthesis, compared with a mutated ACHE prosthesis as device 2, for evaluation of neuronal network circuitry integrity in the presence of Amyloid- beta (Ab) under the conditions of free from tracers and antibodies in spiked NIST SRM 965A human serum. Three categories of Reentrant Energy-Sensory images are presented based on infused brain pulse energies in a matrix of “Sensory Biomarkers” having frequencies over 0.25-333 Hz at free and fixed Ab levels, respectively. Early non-symptomatic epilepsy was indentified and predicted by device 2 due to Pathological High Frequency Oscillation (pHFO) and large areas of 38 µM Ab re-depositions. Device 1 sensitively “feels” Ab damage because of its Frequency Oscillation (HFO) enhanced the hummingbird- like hovering pattern with higher reentrant energy sensitivity of 0.12 pj/bit/s/µm3 without Ab compared with Ab, 13 aj/bit/s/µm3/nM over 3.8-471 nM range over 0.003-4s. Device 1 reliably detected early CR dysfunction privileged to avoid epilepsy.


Keywords: Hummingbird Hovering Flight Pattern, Nanobiomimetic Neuronal Memcapacitor, Circadian Rhythm, Spatial-Temporal Orientation, Energy-Sensory Reentrant Image, Dysfunction of Memory, Epilepsy.


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