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Vol. 191, Issue 8, August 2015, pp. 100-113




In Vitro Restoration of an Amyloid-Beta Altered Network Circuitry in a 'Mutated Biomimetic Acetylcholinesterase' Memristor/Memcapacitor Neural Prosthesis

1 John THORNTON, 2 Charlie MULCHI Jr., 3 Peter T. KISSINGER, 4 * Ellen T. CHEN

1 Bruker Nano, 19 Fortune Dr., Billerica, MA 01821, USA
2 Armo Case, 14020 Crest Hill Lane, Silver Spring, MD 20905, USA
3Department of Chemistry, Purdue University, West Lafayette, IN 47906, USA
4* Advanced Biomimetic Sensors, 11140 Rockville Pike Suite 400, Unit 422 Rockville, MD 20852, USA
1 Tel.: 301-528-2273

E-mail: ellenchen@nanobiomimeticsensors.com


Received: 24 June 2015 /Accepted: 30 July 2015 /Published: 31 August 2015

Digital Sensors and Sensor Sysstems


Abstract: Many diseases involve the ysregulation of acetylcholinesterase (ACHE) causing inappropriate production of the neurotransmitter acetylcholine (ACH). Study of how the ACH actually restores a life threatening neural circuitry damage will provide valuable information for study Alzhermer’s disease. An artificial neuronal device was developed with nanostructured biomimetic mutated ACHE gorge membrane on gold chips having memristor/memcapacitor’s characteristics, served as a model for damaged brain circuitry prosthesis, compared before and after ACH treatments, for in vitro evaluation of the memory restoration in the presence of Amyloid-beta (Ab) under the conditions of free from tracers and antibodies in NIST human serum. The results are presented in three categories in “Energy-Sensory” images. Before ACH treatments, images showed four stages of circuitry damages from non symptomatic to life threatening. After a 15 nM ACH treatment, the circuitry was restored due to the ACH removed Pathological High Frequency Oscillation (pHFO) center during Slow- Waving Sleeping (SWS). After the prosthesis increased hydrophobicity, the High Frequency Oscillation (HFO) was created. Results were compared between the recovered and the “normal brain”: 0.14 vs. 0.47 pJ/bit/µm3 for long-term and 14.0 vs.7.0 aJ/bit/µm3 for short-term memory restoration, respectively. The ratio of Rmax/Rmin value is 6.3-fold higher after the treatment of ACH compared without the treatment in the presence of Ab and the reentry sensitivity increased by 613.8- fold.


Keywords: Nanobiomimetic neuronal memcapacitor, Circadian rhythm, Reentrant-recursive, Spatial-temporal orientation, 3D energy-sensory reentrant map, Memory recovery, Acetylcholine (ACH).


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