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Vol. 215, Issue 8, August 2017, pp. 1-7




Review on Ultra-Sensitive QCM Mass Sensor and Microfluidic for Diagnostic Point of Care

Selemani SEIF, Thomas THUNDERT and * Kenneth CADIEN

University of Alberta, Department of Chemical & Materials Engineering 9211-116 Street NW, Edmonton, Alberta, Canada T6G 1H9
* Tel.: (780) 492 7380

* E-mail: kcadien@ualberta.ca


Received: 14 July 2017 /Accepted: 15 August 2017 /Published: 31 August 2017

Digital Sensors and Sensor Sysstems


Abstract: This review discusses on Quartz Crystal Microbalance (QCM) and microfluidic driven by ultrasonic acoustic forces, as possible alternative technologies to develop compact and portable diagnostic point of care (POC). Extension of QCM to measure 10-15 g/cm2 is possible and development of this technology will open up new business opportunities in public health, life sciences, and material sciences. The experimental results showed that QCM technology can be 1000 times more sensitive, than the currently available mass sensor systems in the market. The target market is on diagnostic POC, focussing on home care, public health, and agriculture and food industry sectors. Some of the challenges discussed are: 1) A centrifuge for blood plasma separation (BPS), and 2) Microfluidic driven by ultrasonic acoustic forces, for separation of suspended particles in the whole blood. We also present an overview of the expected global market growth from 2011 to 2020 and the benefits to the end users.


Keywords: Femtogram, QCM, Microfluidic, Ultrasonic blood plasma separation (BPS), Free-BPS, Whole blood.


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