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Vol. 214, Issue 7, July 2017, pp. 69-84




Observation of Fermi Arc Surface States Induced by Organic Memristive/Memcapacitive Devices
with a Double-Helical Polarized Single-Wall Nanotube Membrane for Direct Chelating
with Matrix Matelloproteinase-2

1 * E. T. CHEN, 2 J. T. THORNTON, 3 S-H. DUH and 4 P.T. KISSINGER

1 Advanced Biomimetic Sensors, Inc., 11140 Rockville Pike, Suite 440, Unit 422, Rockville, MD 20852, USA
2 Bruker Nano, 19 Fortune Dr., Billerica, MA 01821, USA
3 University of Maryland Medical System, 22 South Greene St, Baltimore, MD 21201, USA
4 Department of Chemistry, Purdue University, West Lafayette, IN 47906, USA

E-mail: ellenchen@nanobiomimeticsensors.com


Received: 6 July 2017 /Accepted: 30 July 2017 /Published: 31 July 2017

Digital Sensors and Sensor Sysstems


Abstract: Matrix Matelloproteinase-2 (MMP-2) plays a key role in many diseases. A new type of dual-functioning device was developed for fast, direct ultrasensitive detection of MMP-2. We report a memristive/memcapacitive device with vertex double-helical polarized biomimetic protein nanotubules forming double membranes with potential gradient mimicking mitochondria’s inner double membrane has developed. We also report Fermi arcs with nodes on the surface of the nanostructured membrane was observed at the first time by using a 3D real-time - energy-current dynamic mapping method based on data obtained from the Cyclic Voltammetry (CV) method. The memristive/memcapacitive device comprises a cross- linked organic polymer having single-wall cross-bar polarized nanotube self-assembling membrane (SAM) on a gold chip, under an applied potential, a pair of vertex double- helical circular current flow induced the Fermi arcs states occurrence and these Fermi arcs promoted a direct chelating with zinc ions of the MMP-2 to become possible without any antibody, tracer, or reagent used at room temperature was accomplished. We observed the pair of Dirac Cones became alignment and strengthened with each other in the presence of MMP-2 compared without MMP-2. The MMP-2 can be detected with ag/mL level sensitivity and the value of Detection of Limits (DOL) reached orders of magnitude lower than published reports with simplified procedures by a Chronoamperometry (CA) method and a Double Step Chronopotentiometry (DSCPO) method using NIST SRM 965A standard human serum, respectively. The results show a feasible application for developing the commercial fast and real-time MMP monitoring devices for various diseases.


Keywords: Organic memristive/Memcapacitive devices; Nanobiomimetic polarizable vertex double-helical single-wall crossbar nanotubules; Inducing fermi arcs; Dirac cones; Direct electron-relay transfer system; Spin-berry-phase; Energy harvesting and sensing device.


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