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Vol. 28, Special Issue, April-May 2018, pp. 7-12

 

Bullet

 

Molecularly Imprinted Polymer Sensing Layer for Tetracycline Chemical Sensor
Based on Piezoelectric Quartz Crystal Transducer
 

* Benilda S. EBARVIA and Isaiah E. UBANDO

Department of Science and Technology-Industrial Technology Development Institute DOST Compound, Gen. Santos Avenue, Bicutan, Taguig City, Metro Manila, 1632, Philippines
* Tel.: 632-837-0032 fax: 632-837-0032

* E-mail: bsebarvia@yahoo.com

 

Received: 28 March 2018 /Accepted: 28 May 2018 /Published: 31 May 2018

Digital Sensors and Sensor Sysstems

 

Abstract: Molecularly imprinted polymer (MIP) for tetracycline was prepared via precipitation polymerization at 60°C for 24 h using methacrylic acid as the monomer, trimethylolpropane methacrylate (TRIM) as the crosslinker, 2,2-azobis–isobutyronitrile as initiator, dichloromethane as porogen and tertracycline HCl as template. After template-removal by methanol-acetic acid solvent extraction, the MIP suspension was coated as sensing layer of a piezoelectric quartz crystal transducer. The molecular recognition of tetracycline in the MIP coating was indicated by a corresponding frequency shift of the sensor response. The sensor response was optimized by varying the amount of coating and pH of solution measured. Different parameters like linearity (r=0.9921), sensitivity (41 Hz/ln [conc]), response time (2.4 min), and dynamic range of solutions (1 ´ 10-6 to 1 ´ 10-3 µg/mL tetracycline) were obtained. A decrease in sensitivity and selectivity ratio was observed for oxy- tetracycline and chlortetracycline in the selectivity study done. Acceptable % recovery was observed for milk and honey matrices. The developed tetracycline sensor is a possible cheaper methodology for screening and quantitation of low levels of tetracycline in foods.

 

Keywords: Molecularly imprinted polymer, Tetracycline, Piezoelectric quartz crystal sensor.

 

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