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Vol. 101, Issue 2, February 2009, pp.104-111





Loss of Capacitance Ideality in Label-Free Immuno-Chip


a*Sandro Carrara, aVijayender Bhalla, bLuca Benini, aBruno Samorì

aBiochemistry Department, University of Bologna, Via Irnerio, 48 Bologna, Italy

bDEIS Department, University of Bologna, Viale Risorgimento 2, Bologna, Italy

*Swiss Federal Institute of Technology – Lausanne (EPFL) - EPFL IC ISIM LSI1 - INF 333
(Bâtiment INF) Station 14 CH-1015 Lausanne, Switzerland

E-mail: sandro.carrara@epfl.ch



Received: 20 January 2009   /Accepted: 20 February 2009   /Published: 28 February 2009


Abstract: Improved label-free capacitive detection was very recently demonstrated for both ssDNA and antigen target molecules. That improvement is due to ethylene-glycol alkanethiols monolayers used as linkers for anchoring probe molecules. The presence of ethylene-glycol chains into the thin films greatly reduces time drift, detection error, and non-specific signals. It also increases ideality of the electrochemical interface behavior. However, the ideality of probe surfaces is partially lost when dealing with antibodies. The aim of this paper is to show this loss of ideality by means of capacitance measurements upon the frequency as acquired in label-free detection of cancer markers.


Keywords: Immuno-chip, Capacitance detection, Ion layering, Ethylene-glycol thiols


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