On-line Magazine 'Sensors & Transducers' (S&T e-Digest)
(ISSN 1726- 5479)
Vol. 66, Issue 4, April 2006, pp. 543-552
Quartz Crystal Based Microgravimetric Immunobiosensors
C. Raman SURI
Institute of Microbial Technology, Sector 39-A, Chandigarh - 160036, India
Tel.: +91-172-2695215; fax: +91-172-2690632
Received: 18 April 2006 Accepted: 24 April 2006 Published: 25 April 2006
Abstract. Piezoelectric crystal immunosensors have attracted considerable interest in the last few years since the monitoring of a specific substance is central in many applications. These sensors work on the principle of measuring a small change in resonant frequency of an oscillating piezoelectric crystal due to change in mass on the sensor surface. Because of their low cost and high Q-factors, these miniaturized sensors show fast response time, high sensitivity, and are suitable for mass production using standard fabrication techniques. Arrays of such sensors could be fabricated to cover ranges of a particular sensing property and have the potential for seamless integration with CMOS-based electronics. The present article demonstrates a type of piezoelectric crystal immunosensor using simple design of frequency oscillator and monitoring circuitry for biomedical applications. The basic criterion for immobilizing biomolecules (receptor etc.) on sensor surface for immunoassay application is briefly discussed.
Keywords: Quartz crystal, Frequency oscillator, Receptor, Immunosensors
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