bullet Sensors & Transducers Journal

    (ISSN 1726- 5479)

205.767

2008 e-Impact Factor

25 Top Downloaded Articles

Journal Subscription 2011

Editorial Calendar 2011

Submit an Article

Editorial Board

Current Issue

Sensors & Transducers journal's cover

Sensors & Transducers Journal 2009

Sensors & Transducers Journal 2008

Sensors & Transducers Journal 2007

2000-2002 S&T e-Digest Contents

2003 S&T e-Digest Contents

2004 S&T e-Digest Contents

2005 S&T e-Digest Contents

2006 S&T e-Digest Contents

 

Best Articles 2009

 

 

 

Vol. 9, Special Issue, December 2010, pp.21-27

 

Bullet

Characterization of Microbubble Contrast Agents for Echographic Imaging through Time-Scheduled Size Distribution Measurements

 

Francesco CONVERSANO, Roberto FRANCHINI and Sergio CASCIARO

Institute of Clinical Physiology, Biomedical Engineering Division,
National Council of Research, 73100 Lecce, Italy

Tel.: +39-0832-422310, fax: +39-0832-422341

E-mail: conversano@ifc.cnr.it, roberto.franchini@ifc.cnr.it, sergio.casciaro@cnr.it

 

 

Received: 27 September 2010   /Accepted: 30 November 2010   /Published: 30 December 2010

 

Abstract: Aim of this work was to study the dissolution behaviour of the phospholipid-shelled perfluorobutane microbubbles of an experimental contrast agent for echographic imaging through an innovative methodology based on time-scheduled size distribution measurements. Two different contrast handling procedures were employed and temporal evolution of corresponding microbubble populations was monitored for several hours. Dissolution behaviour of shelled microbubbles resulted to be qualitatively analogous to that theoretically predicted for unshelled perfluorobutane bubbles, with a much longer lifetime due to the shell effect. In particular, mean microbubble diameter, initially around 2 m, first increased to more than 2.6 m and then gradually reduced to less than 1.7 m, with corresponding variations of the effectively employable ultrasound frequencies for imaging purposes. We also demonstrated that excess lipid material is diffused as submicron particle shedding. Finally, we discussed the implications of these results for diagnostic and therapeutic applications involving the studied microbubbles.

 

Keywords: Ultrasound contrast agents, Microbubble sizing, Microbubble counting, Microbubble dissolution, Echographic imaging

 

Acrobat reader logo Click <here> or title of paper to download the full pages article (1.66 Mb)

 

 

 

 

 


1999 - 2010 Copyright , International Frequency Sensor Association (IFSA). All Rights Reserved.


Home - News - Links - Archives - Tools - Standardization - Patents - Marketplace - Projects - Wish List - Subscribe - Search - Membership - Submit Press Release - Twitter

 Members Area -Sensors Portal -Training Courses - S&T Digest - For advertisers - Bookstore - Forums - Polls - Sensor Jobs - e-Shop - Site Map - Video