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Vol. 137, Issue 2, February 2012, pp. 1-9




Application of a Quartz Crystal Microbalance (QCM) Twin Sensor for Selective Label-free Immunoassay to Simultaneous Antigen-antibody Reactions


1 Naoki MIZUTANI, 1 Sergiy KORPOSH, 1 Roman SELYANCHYN, 2 Shunichi WAKAMATSU, and 1* Seung-Woo LEE

1 Graduate School of Environmental Engineering, the University of Kitakyushu, 1-1, Hibikino, Wakamatsu-ku, Kitakyushu, 808-013, Japan

2 Chitose Technical Center, Nihon Dempa Kogyo Co. Ltd., 1-3-1 Kashiwadai-minami, Chitose, Hokkaido 0660009, Japan

* Tel.: +81-093-695-3293, +81-093-695-3384

E-mail: leesw@kitakyu-u.ac.jp


Received: 25 November 2011   /Accepted: 14 February 2012   /Published: 28 February 2012

Digital Sensors and Sensor Sysstems


Abstract: In this work a 30 MHz quartz crystal microbalance (QCM) twin sensor system was used for simultaneous monitoring of antigen-antibody reactions. The twin sensor system provided a significant improvement of the conventional mass-sensitive devices, which allows to undertake simultaneous control and analyte measurements under the same experimental conditions. In the given system one channel of the QCM electrode, fixed in a thermostatic flow cell, was modified with chrome pure human IgG (H-IgG) while the second with chrome pure chicken IgY. The antigen-antibody reaction was measured by admitting affinity pure anti-human IgG (Anti-H-IgG) and affinity pure anti-chicken IgG (Anti-C-IgY) into the flow cell and recording the frequency change caused by the selective adsorption of the complementary antigen on the particular antibody immobilized on the surface of the QCM electrode. The system showed high sensitivity with a limit of detection (LOD) of 62.1 ng/mL and fast response time within 5 min.


Keywords: Mass sensitive twin sensor, Quartz crystal microbalance, Immunoassay, antigen-antibody reaction, Label-free.



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