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Vol. 15, Special Issue, October 2012, pp. 49-58


Selected papers from Nanotech Conference & Expo (NanoTech' 2012),
18-21 June 2012, Santa Clara, California, USA




Ultralow Detection of Bio-markers Using Gold Nanoshells


1 Dhruvinkumar PATEL, Xinghua SUN, Guandong ZHANG, Robert S. KEYNTON, 2 Andre M. GOBIN

University of Louisville, Louisville, KY 40292, USA

E-mail: dnpate01@gmail.com 1, andre.gobin@louisville.edu 2



Received: 14 September 2012   /Accepted: 1 October 2012   /Published: 8 October 2012

Digital Sensors and Sensor Sysstems


Abstract: Gold nanoparticles (AuNPs) as identification markers or labels can be designed for detection of antigens, analytes, biomarkers, or viral particles, in small sample volumes and concentrations, in a very sensitive and specific environment. The focus of this project is to improve the detection of antigen/biomarkers/viral vectors using gold nanoshells (GNS), which results in a change in the surface plasmon resonance (SPR). The assay used in this project is based on aggregation of GNS in presence of antigen or viral vectors. GNS are coated with thiolated–poly(ethylene) glycol–amine (HS-PEG-NH2)-conjugated Protein G (ProG) and Goat anti-rabbit antibody. Our data shows that fully assembled nanoparticles (GNS-PEG-ProG-Anti-rabbit) in presence of antigen, rabbit IgG (Rb IgG), allow detection events at concentrations in the ng/ml to pg/ml range. The lower detection limit of this improved assay was 0.5 pg/mL within 10 mins. This shows a three order of magnitude improvement over that previously reported.


Keywords: Gold nanoshells, Detection, Protein G, Enhanced detection limit, Bio-assay



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